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1

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Lai, Andiliy, Kahraman, Mehmet, Govek, Steven, Nagasawa, Johnny, Bonnefous, Celine, Julien, Jackie, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, Kyoung-jin, Aparicio, Anna, Kaufman, Josh, Qian

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.26 MB

english, 2015

2

Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists

Céline Bonnefous, Jean-Michel Vernier, John H. Hutchinson, Janice Chung, Grace Reyes-Manalo, Theodore Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 174 KB

english, 2005

3

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

Steven P. Govek, Celine Bonnefous, John H. Hutchinson, Theodore Kamenecka, Jeffrey McQuiston, Richard Pracitto, Lucy X. Zhao, Michael F. Gardner, Joyce K. James, Lorrie P. Daggett, Blake A. Rowe, Herv

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 585 KB

english, 2005

4

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

Céline Bonnefous, Jean-Michel Vernier, John H. Hutchinson, Michael F. Gardner, Merryl Cramer, Joyce K. James, Blake A. Rowe, Lorrie P. Daggett, Hervé Schaffhauser, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

5

Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists

Theodore M. Kamenecka, Céline Bonnefous, Steven Govek, Jean-Michel Vernier, John Hutchinson, Janice Chung, Grace Reyes-Manalo, Jeffery J. Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

6

Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor

Joseph E. Payne, Céline Bonnefous, Christian A. Hassig, Kent T. Symons, Xin Guo, Phan-Manh Nguyen, Tami Annable, Paul L. Wash, Timothy Z. Hoffman, Tadimeti S. Rao, Andrew K. Shiau, James W. Malecha, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

7

α-Mercaptoketone based histone deacetylase inhibitors

Paul L. Wash, Timothy Z. Hoffman, Brandon M. Wiley, Céline Bonnefous, Nicholas D. Smith, Michael S. Sertic, Charles M. Lawrence, Kent T. Symons, Phan-Manh Nguyen, Kevin D. Lustig, Xin Guo, Tami Annabl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 375 KB

english, 2008

8

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

Terence G. Hamill, Stephen Krause, Christine Ryan, Celine Bonnefous, Steve Govek, T. Jon Seiders, Nicholas D.P. Cosford, Jeffrey Roppe, Ted Kamenecka, Shil Patel, Raymond E. Gibson, Sandra Sanabria, K

Journal:

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

9

Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors

Sergio G. Durón, Andrew Lindstrom, Céline Bonnefous, Hui Zhang, Xiaohong Chen, Kent T. Symons, Marciano Sablad, Natasha Rozenkrants, Yan Zhang, Li Wang, Nahid Yazdani, Andrew K. Shiau, Stewart A. Nobl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

10

Six-Membered Ring Chelate Complexes of Ru(II): Structural and Photophysical Effects

Abrahamsson, Maria, Becker, Hans-Christian, Hammarström, Leif, Bonnefous, Celine, Chamchoumis, Charles, Thummel, Randolph P.

Journal:

Inorganic Chemistry

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

11

Cyclometalated Complexes of Ru(II) with 2-Aryl Derivatives of Quinoline and 1,10-Phenanthroline

Bonnefous, Céline, Chouai, Abdellatif, Thummel, Randolph P.

Journal:

Inorganic Chemistry

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

12

A luminescent Pt(ii) complex with a terpyridine-like ligand involving a six-membered chelate ring

Hu, Yi-Zhen, Wilson, Michael H., Zong, Ruifa, Bonnefous, Celine, McMillin, David R., Thummel, Randolph P.

Journal:

Dalton Transactions

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

13

Self assembly of a diphenanthrolinylpyrene-bridged CuI trimer

Bonnefous, Céline, Bellec, Nathalie, Thummel, Randolph P.

Journal:

Chemical Communications

Year:

1999

Language:

english

File:

PDF, 157 KB

english, 1999

14

Optimization of an indazole series of selective estrogen receptor degraders: tumor regression in a tamoxifen-resistant breast cancer xenograft

Govek, Steven P., Nagasawa, Johnny Y., Douglas, Karensa L., Lai, Andiliy G., Kahraman, Mehmet, Bonnefous, Celine, Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L., Joseph, James D., Kau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 445 KB

english, 2015

15

Identification of an orally bioavailable chromene-based Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in a model of tamoxifen-resistant breast cancer

Nagasawa, Johnny, Govek, Steven, Kahraman, Mehmet, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, Kyoungjin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gan

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 898 KB

english, 2018

16

Maximizing ER-α degradation maximizes activity in a tamoxifen-resistant breast cancer model: Identification of GDC-0927

Kahraman, Mehmet, Govek, Steven P, Nagasawa, Johnny Y, Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffer, John, Liu, Nhin, Lee, Kyoungjin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 406 KB

english, 2018

17

Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft

Govek, Steven P., Bonnefous, Celine, Julien, Jackaline D., Nagasawa, Johnny Y., Kahraman, Mehmet, Lai, Andiliy G., Douglas, Karensa L., Aparicio, Anna M., Darimont, Beatrice D., Grillot, Katherine L.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 558 KB

english, 2018